| Reaction Details |
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 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
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| Ligand | BDBM50020101 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68522 (CHEMBL676946) |
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| Ki | 1900±n/a nM |
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| Citation |  Rosowsky, A; Bader, H; Kohler, W; Freisheim, JH; Moran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem31:1338-44 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Folylpolyglutamate synthase, mitochondrial |
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| Name: | Folylpolyglutamate synthase, mitochondrial |
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| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64621.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_68676 |
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| Residue: | 587 |
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| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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| BDBM50020101 |
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| n/a |
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| Name | BDBM50020101 |
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| Synonyms: | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-phosphonooxy-butyric acid | CHEMBL281024 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N8O7P |
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| Mol. Mass. | 492.3825 |
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| SMILES | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCOP(O)(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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