| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
|---|
| Ligand | BDBM50020108 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_68382 |
|---|
| Ki | 6000±n/a nM |
|---|
| Citation |  Rosowsky, A; Bader, H; Kohler, W; Freisheim, JH; Moran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem31:1338-44 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Folylpolyglutamate synthase, mitochondrial |
|---|
| Name: | Folylpolyglutamate synthase, mitochondrial |
|---|
| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64621.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_68676 |
|---|
| Residue: | 587 |
|---|
| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
|
|
|
|---|
| BDBM50020108 |
|---|
| n/a |
|---|
| Name | BDBM50020108 |
|---|
| Synonyms: | 5-Amino-2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL431290 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22N8O4 |
|---|
| Mol. Mass. | 426.4292 |
|---|
| SMILES | NCCC[C@H](NC(=O)c1ccc(NCc2cnc3nc(N)[nH]c(=O)c3n2)cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
