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TargetDihydrofolate reductase
LigandBDBM50020100
Substrate/Competitorn/a
Meas. Tech.ChEBML_54452
IC50 26±n/a nM
Citation Rosowsky, ABader, HKohler, WFreisheim, JHMoran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem31:1338-44 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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  Blast E-value cutoff:
BDBM50020100
n/a
NameBDBM50020100
Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-tridecanedioic acid | CHEMBL26326
TypeSmall organic molecule
Emp. Form.C28H38N8O5
Mol. Mass.566.6519
SMILESCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCCCCCCCCCC(O)=O)C(O)=O
Structure
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