| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50227823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72641 (CHEMBL684345) |
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| Ki | 93000±n/a nM |
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| Citation |  Broom, AD Rational design of enzyme inhibitors: multisubstrate analogue inhibitors. J Med Chem32:2-7 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50227823 |
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| n/a |
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| Name | BDBM50227823 |
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| Synonyms: | CHEMBL3392214 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N9O4S |
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| Mol. Mass. | 445.456 |
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| SMILES | Nc1nc(O)c2cc(CSC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c(N)ncnc34)[nH]c2n1 |r| |
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| Structure | 
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