| Reaction Details |
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 | Report a problem with these data |
| Target | Leucyl-cystinyl aminopeptidase |
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| Ligand | BDBM23971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_98526 (CHEMBL706546) |
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| Ki | 20±n/a nM |
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| Citation |  Harbeson, SL; Rich, DH Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. J Med Chem32:1378-92 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Leucyl-cystinyl aminopeptidase |
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| Name: | Leucyl-cystinyl aminopeptidase |
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| Synonyms: | Cystinyl aminopeptidase | GP160 | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | Irap | LCAP_RAT | Leucyl-cystinyl aminopeptidase | Lnpep | Otase | Oxytocinase | P-LAP | Placental leucine aminopeptidase | Vesicle protein of 165 kDa | Vp165 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117179.39 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_98523 |
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| Residue: | 1025 |
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| Sequence: | METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGE
HEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVV
AVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELS
LHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYH
EQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAAR
SAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVA
FIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLV
AIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWW
NDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQI
EEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKT
LDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVT
DGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNP
YVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLE
KLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMAT
KLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASS
ADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGS
YTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKT
LTLWL
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| BDBM23971 |
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| n/a |
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| Name | BDBM23971 |
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| Synonyms: | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid | Bestatin | CHEMBL29292 | Ubenimex |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24N2O4 |
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| Mol. Mass. | 308.3728 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |
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| Structure | 
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