| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
|---|
| Ligand | BDBM50005685 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_140183 |
|---|
| Ki | 1.7±n/a nM |
|---|
| Citation |  Leader, H; Smejkal, RM; Payne, CS; Padilla, FN; Doctor, BP; Gordon, RK; Chiang, PK Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates. J Med Chem32:1522-8 (1989) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51555.53 |
|---|
| Organism: | RAT |
|---|
| Description: | P10980 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM50005685 |
|---|
| n/a |
|---|
| Name | BDBM50005685 |
|---|
| Synonyms: | 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester | 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester(Aprophen) | 2-(diethylamino)ethyl 2,2-diphenylpropanoate | Aprofene | Aprophen | CHEMBL26505 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H27NO2 |
|---|
| Mol. Mass. | 325.4446 |
|---|
| SMILES | CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
