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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50005685
Substrate/Competitorn/a
Meas. Tech.ChEBML_140183
Ki 1.7±n/a nM
Citation Leader HSmejkal RMPayne CSPadilla FNDoctor BPGordon RKChiang PK Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates. J Med Chem 32:1522-8 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic receptor M2 and M3
Synonyms:CHRM2 | Cholinergic, muscarinic M2
Type:Enzyme Catalytic Domain
Mol. Mass.:51555.53
Organism:RAT
Description:P10980
Residue:466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM50005685
n/a
NameBDBM50005685
Synonyms:2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester | 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester(Aprophen) | 2-(diethylamino)ethyl 2,2-diphenylpropanoate | Aprofene | Aprophen | CHEMBL26505
TypeSmall organic molecule
Emp. Form.C21H27NO2
Mol. Mass.325.4446
SMILESCCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1
Structure
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