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TargetPhenylethanolamine N-methyltransferase
LigandBDBM13014
Substrate/Competitorn/a
Meas. Tech.ChEBML_152586
Ki 3±n/a nM
Citation Girard, GR; Bondinell, WE; Hillegass, LM; Holden, KG; Pendleton, RG; Uzinskas, I Tetrahydrothiadiazoloisoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase. J Med Chem32:1566-71 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Phenylethanolamine N-methyltransferase
Name:Phenylethanolamine N-methyltransferase
Synonyms:Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:Enzyme
Mol. Mass.:30852.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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  Blast E-value cutoff:
BDBM13014
n/a
NameBDBM13014
Synonyms:7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | CHEMBL287837 | CHEMBL541797 | SKF 64139 | tetrahydroisoquinoline (THIQ) analogue
TypeSmall organic molecule
Emp. Form.C9H9Cl2N
Mol. Mass.202.08
SMILESClc1ccc2CCNCc2c1Cl
Structure
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