| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50013147 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_146388 |
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| Ki | 16±n/a nM |
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| Citation |  Halfpenny, PR; Horwell, DC; Hughes, J; Hunter, JC; Rees, DC Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives. J Med Chem33:286-91 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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|
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| BDBM50013147 |
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| n/a |
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| Name | BDBM50013147 |
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| Synonyms: | 2-Benzo[b]thiophen-4-yl-N-(4,5-dimethoxy-2-pyrrolidin-1-yl-cyclohexyl)-N-methyl-acetamide; hydrochloride | CHEMBL544321 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32N2O3S |
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| Mol. Mass. | 416.577 |
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| SMILES | CO[C@H]1CC([C@H](C[C@H]1OC)N1CCCC1)N(C)C(=O)Cc1cccc2sccc12 |
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| Structure | 
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