| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50014247 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_131451 |
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| Ki | 9.1±n/a nM |
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| Citation |  Maryanoff, BE; Vaught, JL; Shank, RP; McComsey, DF; Costanzo, MJ; Nortey, SO Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem33:2793-7 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | Dat | Dat1 | Dopamine transporter | SC6A3_MOUSE | Slc6a3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 68809.06 |
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| Organism: | MOUSE |
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| Description: | Dopamine Transporter SLC6A3 MOUSE::Q61327 |
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| Residue: | 619 |
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| Sequence: | MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDR
QLVDRGEVRQFTLRHWLLV
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| BDBM50014247 |
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| n/a |
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| Name | BDBM50014247 |
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| Synonyms: | (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine | 3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) | CHEMBL94739 | Femoxetine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25NO2 |
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| Mol. Mass. | 311.418 |
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| SMILES | COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 |
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| Structure | 
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