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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50013962
Substrate/Competitorn/a
Meas. Tech.ChEBML_201137
Ki 456±n/a nM
Citation de Costa BRRice KCBowen WDThurkauf ARothman RBBand LJacobson AERadesca LContreras PCGray NM Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. J Med Chem 33:3100-10 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | SIG-1R | SR-BP | SR31747-binding protein | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Sigma 0 HUMAN::Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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  Blast E-value cutoff:
BDBM50013962
n/a
NameBDBM50013962
Synonyms:2-(2H-1,3-benzodioxol-5-yl)-N-methyl-N-[(2R)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide | 2-Benzo[1,3]dioxol-5-yl-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide
TypeSmall organic molecule
Emp. Form.C20H28N2O3
Mol. Mass.344.4479
SMILESCN(C1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc2OCOc2c1
Structure
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