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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50013955
Substrate/Competitorn/a
Meas. Tech.ChEMBL_201275 (CHEMBL804964)
Ki 1372±n/a nM
Citation de Costa, BRRice, KCBowen, WDThurkauf, ARothman, RBBand, LJacobson, AERadesca, LContreras, PCGray, NM Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes. J Med Chem33:3100-10 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50013955
n/a
NameBDBM50013955
Synonyms:N-Methyl-2-naphthalen-2-yl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide | N-methyl-2-(naphthalen-2-yl)-N-[(2S)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide
TypeSmall organic molecule
Emp. Form.C23H30N2O
Mol. Mass.350.4971
SMILESCN(C1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc2ccccc2c1
Structure
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