| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50368038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210101 |
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| IC50 | 72000±n/a nM |
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| Citation |  Archibald, JL; Bradley, G; Opalko, A; Ward, TJ; White, JC; Ennis, C; Shepperson, NB Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines. J Med Chem33:646-52 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50368038 |
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| n/a |
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| Name | BDBM50368038 |
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| Synonyms: | CHEMBL1203655 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N3O7 |
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| Mol. Mass. | 481.4978 |
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| SMILES | CCOC(=O)C1=C(COCCc2ccncc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:18| |
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| Structure | 
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