| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase large subunit |
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| Ligand | BDBM50013370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195110 |
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| IC50 | 29000±n/a nM |
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| Citation |  Gaudreau, P; Paradis, H; Langelier, Y; Brazeau, P Synthesis and inhibitory potency of peptides corresponding to the subunit 2 C-terminal region of herpes virus ribonucleotide reductases. J Med Chem33:723-30 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase large subunit |
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| Name: | Ribonucleoside-diphosphate reductase large subunit |
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| Synonyms: | ICP6 | R1 | RIR1 | RIR1_HHV11 | Ribonucleoside-diphosphate reductase large chain | Ribonucleoside-diphosphate reductase large subunit | Ribonucleotide reductase 136 kDa subunit | Ribonucleotide reductase large subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 124049.68 |
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| Organism: | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_195109 |
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| Residue: | 1137 |
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| Sequence: | MASRPAASSPVEARAPVGGQEAGGPSAATQGEAAGAPLAHGHHVYCQRVNGVMVLSDKTP
GSASYRISDNNFVQCGSNCTMIIDGDVVRGRPQDPGAAASPAPFVAVTNIGAGSDGGTAV
VAFGGTPRRSAGTSTGTQTADVPTEALGGPPPPPRFTLGGGCCSCRDTRRRSAVFGGEGD
PVGPAEFVSDDRSSDSDSDDSEDTDSETLSHASSDVSGGATYDDALDSDSSSDDSLQIDG
PVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPEAGAGLAADPAVARDDAEGLS
DPRPRLGTGTAYPVPLELTPENAEAVARFLGDAVNREPALMLEYFCRCAREETKRVPPRT
FGSPPRLTEDDFGLLNYALVEMQRLCLDVPPVPPNAYMPYYLREYVTRLVNGFKPLVSRS
ARLYRILGVLVHLRIRTREASFEEWLRSKEVALDFGLTERLREHEAQLVILAQALDHYDC
LIHSTPHTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIAL
GREGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNKATLRAIT
SNVSAILARNGGIGLCVQAFNDSGPGTASVMPALKVLDSLVAAHNKESARPTGACVYLEP
WHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWTLFDRDTS
MSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMFKDAVNRHYIY
DTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMV
NIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDLESAEFQDLNKHIAEVMLL
SAMKTSNALCVRGARPFNHFKRSMYRAGRFHWERFPDARPRYEGEWEMLRQSMMKHGLRN
SQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFSGKRLL
EVMDSLDAKQWSVAQALPCLEPTHPLRRFKTAFDYDQKLLIDLCADRAPYVDHSQSMTLY
VTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFGGDDNIVCMSCAL
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| BDBM50013370 |
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| n/a |
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| Name | BDBM50013370 |
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| Synonyms: | CHEMBL2371362 | Tyr-Ala-Gly-Thr-Val-Val-Asn-Asp-Leu |
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| Type | Small organic molecule |
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| Emp. Form. | C42H66N10O15 |
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| Mol. Mass. | 951.0314 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(C)C)C(O)=O |
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| Structure | 
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