| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50013386 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_146690 |
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| IC50 | 1.8±n/a nM |
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| Citation |  Olsen, LD; Klein, P; Nelson, WL; Yao, YH; Simon, EJ Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol. J Med Chem33:737-41 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | Mu opioid receptor | OPIATE Mu | OPRM1 | OPRM_BOVIN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45038.37 |
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| Organism: | CALF |
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| Description: | OPIATE Mu 2 0 CALF::P79350 |
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| Residue: | 401 |
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| Sequence: | MDSGAVPTNASNCTDPFTHPSSCSPAPSPSSWVNFSHLEGNLSDPCGPNRTELGGSDRLC
PSAGSPSMITAIIIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA
TSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALD
LRTPRNAKIINICNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVF
IFAFIMPILIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH
IYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSST
IEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETTPLP
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| BDBM50013386 |
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| n/a |
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| Name | BDBM50013386 |
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| Synonyms: | 4,5alpha-Epoxy-3,6alpha, 14-trihydroxy-6beta-(2-carboxyallyl)-17-(cyclopropylmethyl) morphinnan gama-lactone | 4,5alpha-Epoxy-3,6alpha, 14-trihydroxy-6beta-(2-carboxyallyl)-17-methylmorphinnan gama-lactone | 4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-yl lactone | Naltrexone analogue |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27NO5 |
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| Mol. Mass. | 409.4749 |
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| SMILES | Oc1ccc2CC3N(CC4CC4)CC[C@@]45C(Oc1c24)C1(CC(=C)C(=O)O1)CCC35O |TLB:29:28:18.4.5:7.13.12,THB:8:7:28:18.4.5,27:28:18.4.5:7.13.12,17:18:28:7.13.12| |
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| Structure | 
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