| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50007907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195055 |
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| IC50 | 4600±n/a nM |
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| Citation |  Jie, L; Van Aerschot, A; Balzarini, J; Janssen, G; Busson, R; Hoogmartens, J; De Clercq, E; Herdewijn, P 5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity. J Med Chem33:2481-7 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50007907 |
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| n/a |
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| Name | BDBM50007907 |
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| Synonyms: | CHEMBL3350647 | alpha,beta-methylene AzddTPP |
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| Type | Small organic molecule |
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| Emp. Form. | C12H20N5O13P3 |
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| Mol. Mass. | 535.2342 |
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| SMILES | CC1C(=O)NC(=O)N([C@H]2C[C@H](N=[N+]=[N-])[C@@H](COCP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C1=C |
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| Structure | 
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