| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50010282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_32104 (CHEMBL644305) |
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| IC50 | 5±n/a nM |
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| Citation |  DuPriest, MT; Griffin, BW; Kuzmich, D; McNatt, LG Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. J Med Chem34:3229-34 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50010282 |
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| n/a |
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| Name | BDBM50010282 |
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| Synonyms: | 2,7-difluorospiro[9H-fluorene-9,3'-(tetrahydro-1'H-pyrrole)]-2',5'-dione | CHEMBL418832 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9F2NO2 |
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| Mol. Mass. | 285.245 |
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| SMILES | Fc1ccc2-c3ccc(F)cc3C3(CC(=O)NC3=O)c2c1 |
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| Structure | 
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