| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50012209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_45238 (CHEMBL658941) |
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| Ki | 1.34±n/a nM |
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| Citation |  Prugh, JD; Hartman, GD; Mallorga, PJ; McKeever, BM; Michelson, SR; Murcko, MA; Schwam, H; Smith, RL; Sondey, JM; Springer, JP New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides. J Med Chem34:1805-18 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50012209 |
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| n/a |
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| Name | BDBM50012209 |
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| Synonyms: | 5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,3-b]thiophene-2-sulfonic acid amide; hydrochloride | CHEMBL554425 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H20N2O4S3 |
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| Mol. Mass. | 364.504 |
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| SMILES | COCCN(CCOC)Cc1cc2cc(sc2s1)S(N)(=O)=O |
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| Structure | 
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