| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a/A2b |
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| Ligand | BDBM50009515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_30534 (CHEMBL643181) |
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| IC50 | 24±n/a nM |
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| Citation |  Francis, JE; Webb, RL; Ghai, GR; Hutchison, AJ; Moskal, MA; deJesus, R; Yokoyama, R; Rovinski, SL; Contardo, N; Dotson, R Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines. J Med Chem34:2570-9 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a/A2b |
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| Name: | Adenosine receptor A2a/A2b |
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| Synonyms: | Adenosine A2 receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 30560 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Adenosine receptor A2b |
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| Synonyms: | AA2BR_RAT | Adenosine receptor | Adora2b |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36378.84 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_32934 |
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| Residue: | 332 |
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| Sequence: | MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFA
IPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGT
RARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYS
FHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
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| Component 2 |
| Name: | Adenosine receptor A2a |
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| Synonyms: | AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45015.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat A2A receptors expressed in CHO cells. |
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| Residue: | 410 |
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| Sequence: | MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFA
ITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKG
IIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAF
VLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALC
WLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRT
HVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGL
GGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
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| BDBM50009515 |
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| n/a |
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| Name | BDBM50009515 |
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| Synonyms: | 2-[6-Amino-2-(2-hydroxy-2-phenyl-propylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol | CHEMBL2021340 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N6O5 |
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| Mol. Mass. | 402.4045 |
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| SMILES | Nc1nc(NC[C@@H](O)c2ccccc2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
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| Structure | 
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