| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha/beta/gamma type |
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| Ligand | BDBM50229928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_152964 |
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| IC50 | 38000±n/a nM |
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| Citation |  Shearer, BG; Sullivan, JP; Carter, JP; Mathew, RM; Waid, P; Connor, JR; Patch, RJ; Burch, RM Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors. J Med Chem34:2928-31 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha/beta/gamma type |
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| Name: | Protein kinase C alpha/beta/gamma type |
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| Synonyms: | Protein kinase C, PKC; classical |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 162381 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_RAT | Pkca | Prkca | Protein kinase C (PKC) | Protein kinase C alpha | Protein kinase C alpha type |
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| Type: | Protein |
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| Mol. Mass.: | 76797.67 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P05696 |
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| Residue: | 672 |
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| Sequence: | MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| Component 2 |
| Name: | Protein kinase C beta type |
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| Synonyms: | KPCB_RAT | PKC, rat brain | Pkcb | Prkcb | Prkcb1 | Protein Kinase C | Protein kinase C (PKC) | Protein kinase C beta |
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| Type: | Enzyme Mixture |
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| Mol. Mass.: | 76755.54 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | PKC from rat brain is known to contain predominately the conventional PKC isoforms, alpha, beta I, beta II, gamma. |
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| Residue: | 671 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEE
LRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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| Component 3 |
| Name: | Protein kinase C gamma type |
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| Synonyms: | KPCG_RAT | Pkcc | Pkcg | Prkcc | Prkcg | Protein kinase C (PKC) | Protein kinase C gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78367.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_152979 |
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| Residue: | 697 |
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| Sequence: | MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGEA
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRL
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDSKRCFFGASPGRLHISDFSFLMVLGKG
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
LKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
GPDGEPTIRAHGFFRWIDWERLERLEIAPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
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| BDBM50229928 |
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| n/a |
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| Name | BDBM50229928 |
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| Synonyms: | CHEMBL97998 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H54N4O2 |
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| Mol. Mass. | 466.7433 |
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| SMILES | [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCCC |
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| Structure | 
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