Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50002822 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_154987 (CHEMBL882497) |
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Ki | 110±n/a nM |
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Citation | Girotra, NN; Biftu, T; Ponpipom, MM; Acton, JJ; Alberts, AW; Bach, TN; Ball, RG; Bugianesi, RL; Parsons, WH; Chabala, JC Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. J Med Chem35:3474-82 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39219.60 |
Organism: | Homo sapiens (Human) |
Description: | PAF Platelet activating factor PTAFR HUMAN::P25105 |
Residue: | 342 |
Sequence: | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
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BDBM50002822 |
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n/a |
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Name | BDBM50002822 |
Synonyms: | (-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n-propoxy-5-[3-(phosphonooxy)propoxy]phenyl]-5-(3,4,5-trimethoxypheny1) tetrahydrofuran Monopotassium Salt | CHEMBL325491 |
Type | Small organic molecule |
Emp. Form. | C28H38O13PS |
Mol. Mass. | 645.633 |
SMILES | CCCOc1c(OCCCOP(O)([O-])=O)cc(cc1S(=O)(=O)CC(C)=O)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1 |
Structure |
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