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TargetPlatelet-activating factor receptor
LigandBDBM50002822
Substrate/Competitorn/a
Meas. Tech.ChEMBL_154987 (CHEMBL882497)
Ki 110±n/a nM
Citation Girotra, NNBiftu, TPonpipom, MMActon, JJAlberts, AWBach, TNBall, RGBugianesi, RLParsons, WHChabala, JC Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. J Med Chem35:3474-82 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Platelet-activating factor receptor
Name:Platelet-activating factor receptor
Synonyms:PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:39219.60
Organism:Homo sapiens (Human)
Description:PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50002822
n/a
NameBDBM50002822
Synonyms:(-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n-propoxy-5-[3-(phosphonooxy)propoxy]phenyl]-5-(3,4,5-trimethoxypheny1) tetrahydrofuran Monopotassium Salt | CHEMBL325491
TypeSmall organic molecule
Emp. Form.C28H38O13PS
Mol. Mass.645.633
SMILESCCCOc1c(OCCCOP(O)([O-])=O)cc(cc1S(=O)(=O)CC(C)=O)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Structure
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