Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50002823

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_154984 (CHEMBL765337)

3.2±n/a nM

Citation

Girotra, NN; Biftu, T; Ponpipom, MM; Acton, JJ; Alberts, AW; Bach, TN; Ball, RG; Bugianesi, RL; Parsons, WH; Chabala, JC Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. J Med Chem35:3474-82 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

39219.60

Organism:

Homo sapiens (Human)

Description:

PAF Platelet activating factor PTAFR HUMAN::P25105

Residue:

342

Sequence:

MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN

BDBM50002823

n/a

Name

BDBM50002823

Synonyms:

2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-benzenesulfonyl}-ethanol | CHEMBL299944 | L-680573 | MK-287

Type

Small organic molecule

Emp. Form.

C25H34O9S

Mol. Mass.

510.597

SMILES

CCCOc1c(OC)cc(cc1S(=O)(=O)CCO)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1

Structure