| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM50003244 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_45064 (CHEMBL659847) |
|---|
| Ki | 4±n/a nM |
|---|
| Citation |  Hartman, GD; Halczenko, W; Smith, RL; Sugrue, MF; Mallorga, PJ; Michelson, SR; Randall, WC; Schwam, H; Sondey, JM 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors. J Med Chem35:3822-31 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM50003244 |
|---|
| n/a |
|---|
| Name | BDBM50003244 |
|---|
| Synonyms: | 4-(3-Diethylaminomethyl-4-hydroxy-benzenesulfonyl)-furan-2-sulfonic acid amide; hydrochloride | CHEMBL538536 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H20N2O6S2 |
|---|
| Mol. Mass. | 388.459 |
|---|
| SMILES | CCN(CC)Cc1cc(ccc1O)S(=O)(=O)c1coc(c1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
