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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Delta-type/Kappa-type/Mu-type opioid receptor | ||
| Ligand | BDBM50001713 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_145721 | ||
| IC50 | 2.4±n/a nM | ||
| Citation |  Klein, P; Nelson, WL O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay. J Med Chem35:4589-94 (1993) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Delta-type/Kappa-type/Mu-type opioid receptor | |||
| Name: | Delta-type/Kappa-type/Mu-type opioid receptor | ||
| Synonyms: | Opioid receptors; mu/kappa/delta | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of ChEMBL is 357797 | ||
| Components: | This complex has 3 components. | ||
| Component 1 | |||
| Name: | Mu-type opioid receptor | ||
| Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 44789.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35372 | ||
| Residue: | 400 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Kappa-type opioid receptor | ||
| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 42648.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41145 | ||
| Residue: | 380 | ||
| Sequence: |
| ||
| Component 3 | |||
| Name: | Delta-type opioid receptor | ||
| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40382.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. | ||
| Residue: | 372 | ||
| Sequence: |
| ||
| BDBM50001713 | |||
| n/a | |||
| Name | BDBM50001713 | ||
| Synonyms: | CHEMBL143815 | methyl 2-[19-(1-hydroxy-1-methylbutyl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7(12),8,10,16-tetraen-11-yloxymethyl]acrylate | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H39NO6 | ||
| Mol. Mass. | 509.6338 | ||
| SMILES | CCC[C@@](C)(O)[C@H]1C[C@]23C=C[C@]1(OC)[C@@H]1Oc4c5c(C[C@H]2N(C)CC[C@@]315)ccc4OCC(=C)C(=O)OC |wU:3.2,20.22,wD:25.29,14.15,8.8,6.5,11.12,3.4,c:9,(9.11,-3.65,;7.57,-3.65,;6.8,-2.32,;5.26,-2.32,;5.23,-.78,;5.65,-3.81,;3.72,-2.32,;2.95,-.99,;1.41,-.96,;1.41,-2.5,;2.92,-2.11,;2.92,-3.65,;3.69,-5,;5.23,-5,;1.38,-3.65,;-.18,-4.02,;-1.65,-3.62,;-.88,-2.29,;-1.65,-.96,;-.9,.37,;.64,.37,;1.03,1.86,;1.97,3.07,;-.3,1.09,;-.72,-1.52,;.64,-2.29,;-3.19,-.96,;-3.96,-2.29,;-3.19,-3.62,;-3.96,-4.95,;-5.5,-4.95,;-6.27,-6.31,;-5.5,-7.64,;-7.81,-6.31,;-8.58,-7.64,;-8.58,-4.95,;-7.81,-3.62,)| | ||
| Structure | 
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