| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aminopeptidase N |
|---|
| Ligand | BDBM50002037 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_35492 (CHEMBL646402) |
|---|
| IC50 | 45±n/a nM |
|---|
| Citation |  Fournié-Zaluski, MC; Coric, P; Turcaud, S; Bruetschy, L; Lucas, E; Noble, F; Roques, BP Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation. J Med Chem35:1259-66 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aminopeptidase N |
|---|
| Name: | Aminopeptidase N |
|---|
| Synonyms: | AMPN_PIG | ANPEP | AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N (APN) | CD_antigen=CD13 | Microsomal aminopeptidase | gp130 | pAPN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 108810.25 |
|---|
| Organism: | Sus scrofa (Pig) |
|---|
| Description: | P15145 |
|---|
| Residue: | 963 |
|---|
| Sequence: | MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAIT
LDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHS
KKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGE
LADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTA
LSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWAR
PNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYREN
ALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHA
EPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIR
MLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWT
LQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRD
VSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIY
DSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLR
KQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDP
ENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNR
YLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQ
GVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFI
EHS
|
|
|
|---|
| BDBM50002037 |
|---|
| n/a |
|---|
| Name | BDBM50002037 |
|---|
| Synonyms: | 2-(4-Hydroxy-phenyl)-1-mercaptomethyl-ethyl-ammonium |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H14NOS |
|---|
| Mol. Mass. | 184.278 |
|---|
| SMILES | [NH3+]C(CS)Cc1ccc(O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
