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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50005688
Substrate/Competitorn/a
Meas. Tech.ChEMBL_157548
Ki 0.400000±n/a nM
Citation Tam TFCarrière JMacDonald DCastelhano ALPliura DHDewdney NJThomas EMBach CBarnett JChan H Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides. J Med Chem 35:1318-20 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
BDBM50005688
n/a
NameBDBM50005688
Synonyms:CHEMBL3085518 | N*1*-[1-Benzyl-3-(2-tert-butylcarbamoyl-pyrrolidin-1-yl)-2-hydroxy-3-oxo-propyl]-2-[2-(naphthalen-1-yloxy)-acetylamino]-succinamide
TypeSmall organic molecule
Emp. Form.C35H43N5O7
Mol. Mass.645.7452
SMILESCC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)COc1cccc2ccccc12
Structure
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