| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A/1B/1D/1F |
|---|
| Ligand | BDBM50031475 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_799 (CHEMBL615403) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Flynn, DL; Zabrowski, DL; Becker, DP; Nosal, R; Villamil, CI; Gullikson, GW; Moummi, C; Yang, DC SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. J Med Chem35:1486-9 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1A/1B/1D/1F |
|---|
| Name: | 5-hydroxytryptamine receptor 1A/1B/1D/1F |
|---|
| Synonyms: | Serotonin 1 (5-HT1) receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 193825 |
|---|
| Components: | This complex has 4 components. |
|---|
| Component 1 |
| Name: | 5-hydroxytryptamine receptor 1D |
|---|
| Synonyms: | 5-HT-1D | 5-HT1D | 5-hydroxytryptamine receptor 1D | 5HT1D_RAT | Htr1d | Serotonin 1 (5-HT1) receptor | Serotonin 1B/1D receptor | Serotonin receptor 1D |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41551.75 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT1D HTR1D RAT::P28565 |
|---|
| Residue: | 374 |
|---|
| Sequence: | MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTI
LLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT
ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHE
EMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQ
LITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTL
GIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDF
RQAFQRVVHFRKAS
|
|
|
|---|
| Component 2 |
| Name: | 5-hydroxytryptamine receptor 1A |
|---|
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46445.29 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Binding assays were performed using rat hippocampal membranes. |
|---|
| Residue: | 422 |
|---|
| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
|
|
|
|---|
| Component 3 |
| Name: | 5-hydroxytryptamine receptor 1B |
|---|
| Synonyms: | 5-HT-1B | 5-HT1B | 5-hydroxytryptamine receptor 1B (5HT1B) | 5HT1B_RAT | 5ht1b | Htr1b | Serotonin 1 (5-HT1) receptor | Serotonin 1B/1D receptor | Serotonin receptor 1B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43173.33 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P28564 |
|---|
| Residue: | 386 |
|---|
| Sequence: | MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATT
LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDF
WLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPP
FFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP
NKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKL
MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLI
NPIIYTMSNEDFKQAFHKLIRFKCTG
|
|
|
|---|
| Component 4 |
| Name: | 5-hydroxytryptamine receptor 1F |
|---|
| Synonyms: | 5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | 5HT1F_RAT | 5ht1f | Htr1f | Serotonin 1 (5-HT1) receptor | Serotonin 1f (5-HT1f) receptor | Serotonin receptor 1F |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41896.93 |
|---|
| Organism: | RAT |
|---|
| Description: | 5-HT1F HTR1F RAT::P30940 |
|---|
| Residue: | 366 |
|---|
| Sequence: | MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINCLVITAIIVTRKLHHPANY
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQGLCDLWLSVDIICCTCSILHLSAIALD
RYRAITDAVEYARKRTPRHAGITITTVWVISVFISVPPLFWRHQGNSRDDQCIIKHDHIV
STIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVLLESGEKSIKL
VSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLGLILG
AFVICWLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
LVRCRN
|
|
|
|---|
| BDBM50031475 |
|---|
| n/a |
|---|
| Name | BDBM50031475 |
|---|
| Synonyms: | 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((R)-methoxy)-benzamide | 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide | 4-Amino-N-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide | CHEMBL27846 | ZACOPRIDE,S |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H20ClN3O2 |
|---|
| Mol. Mass. | 309.791 |
|---|
| SMILES | COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CN2CCC1CC2 |wU:13.13,TLB:12:13:17.16:19.20,(11.11,-14.18,;11.11,-12.63,;9.77,-11.88,;8.43,-12.66,;7.09,-11.89,;5.75,-12.66,;7.09,-10.33,;5.76,-9.57,;8.43,-9.56,;9.75,-10.36,;11.09,-9.59,;11.11,-8.04,;12.44,-10.36,;13.77,-9.59,;14.8,-8.58,;16.63,-8.19,;17.94,-9.45,;16.9,-10.39,;15.57,-9.1,;15.88,-7.77,;16.88,-7.14,)| |
|---|
| Structure | 
|
|---|
Search and Browse
