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TargetFolylpolyglutamate synthase, mitochondrial
LigandBDBM50005866
Substrate/Competitorn/a
Meas. Tech.ChEBML_68543
Ki 2000000±n/a nM
Citation Rosowsky, AForsch, RAReich, VEFreisheim, JHMoran, RG Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. J Med Chem35:1578-88 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Folylpolyglutamate synthase, mitochondrial
Name:Folylpolyglutamate synthase, mitochondrial
Synonyms:FOLC_MOUSE | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Fpgs | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:PROTEIN
Mol. Mass.:64969.76
Organism:Mus musculus
Description:ChEMBL_68680
Residue:587
Sequence:
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNAS
YLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRN
YGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGA
HQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVW
PGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRD
SAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEK
QASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSL
PRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
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  Blast E-value cutoff:
BDBM50005866
n/a
NameBDBM50005866
Synonyms:2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid | CHEMBL294973
TypeSmall organic molecule
Emp. Form.C21H25N6O7P
Mol. Mass.504.433
SMILESCCOP(O)(=O)CCC(NC(=O)c1ccc(NCc2cnc3nc(N)[nH]c(=O)c3c2)cc1)C(O)=O
Structure
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