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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA topoisomerase 1 | ||
| Ligand | BDBM50045381 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_208261 | ||
| IC50 | 76±n/a nM | ||
| Citation |  Wall, ME; Wani, MC; Nicholas, AW; Manikumar, G; Tele, C; Moore, L; Truesdale, A; Leitner, P; Besterman, JM Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. J Med Chem36:2689-700 (1993) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA topoisomerase 1 | |||
| Name: | DNA topoisomerase 1 | ||
| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 90771.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11387 | ||
| Residue: | 765 | ||
| Sequence: |
| ||
| BDBM50045381 | |||
| n/a | |||
| Name | BDBM50045381 | ||
| Synonyms: | (20R)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | (20RS)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | (20S)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | CHEMBL90761 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17N3O6 | ||
| Mol. Mass. | 407.3762 | ||
| SMILES | CCC1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5c(N)c4cc3Cn1c2=O | ||
| Structure | 
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