Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | DNA topoisomerase 1 | ||
Ligand | BDBM50045381 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_208261 (CHEMBL813222) | ||
IC50 | 69±n/a nM | ||
Citation | Wall, ME; Wani, MC; Nicholas, AW; Manikumar, G; Tele, C; Moore, L; Truesdale, A; Leitner, P; Besterman, JM Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. J Med Chem36:2689-700 (1993) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
DNA topoisomerase 1 | |||
Name: | DNA topoisomerase 1 | ||
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 90771.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11387 | ||
Residue: | 765 | ||
Sequence: |
| ||
BDBM50045381 | |||
n/a | |||
Name | BDBM50045381 | ||
Synonyms: | (20R)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | (20RS)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | (20S)-15-amino-7-ethyl-7-hydroxy-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | CHEMBL90761 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H17N3O6 | ||
Mol. Mass. | 407.3762 | ||
SMILES | CCC1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5c(N)c4cc3Cn1c2=O | ||
Structure |