Ki Summary

Reaction Details

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Target

Substance-K receptor

Ligand

BDBM50001447

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_141788

3700±n/a nM

Citation

Rosen, T; Seeger, TF; McLean, S; Desai, MC; Guarino, KJ; Bryce, D; Pratt, K; Heym, J; Chalabi, PM; Windels, JH Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand. J Med Chem36:3197-201 (1993) [PubMed]

More Info.:

Get all data from this article, Assay Method

Substance-K receptor

Name:

Substance-K receptor

Synonyms:

NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

45106.00

Organism:

GUINEA PIG

Description:

Neurokinin NK2 TACR2 GUINEA PIG::Q64077

Residue:

402

Sequence:

MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILA
HQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATK
CVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLR
HLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMA
GDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS

BDBM50001447

n/a

Name

BDBM50001447

Synonyms:

CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(NeurokininA)

Type

Small organic molecule

Emp. Form.

C50H80N14O14S

Mol. Mass.

1133.321

SMILES

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(N)=O

Structure