Reaction Details |
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Target | Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
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Ligand | BDBM50042725 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_216149 (CHEMBL817032) |
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Ki | 3000±n/a nM |
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Citation | Mach, RH; Luedtke, RR; Unsworth, CD; Boundy, VA; Nowak, PA; Scripko, JG; Elder, ST; Jackson, JR; Hoffman, PL; Evora, PH 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. J Med Chem36:3707-20 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
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Name: | Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
Synonyms: | Adrenergic receptor alpha-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 935397 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Alpha-2C adrenergic receptor |
Synonyms: | ADA2C_RAT | Adra2c | Adrenergic receptor alpha | Alpha-2C adrenergic receptor | adrenergic Alpha2 | adrenergic Alpha2C |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49890.50 |
Organism: | RAT |
Description: | adrenergic Alpha2 0 RAT::P22086 |
Residue: | 458 |
Sequence: | MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRR
GGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRAR
SSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFW
IGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
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Component 2 |
Name: | Alpha-2B adrenergic receptor |
Synonyms: | ADA2B_RAT | Adra2b | Adrenergic receptor alpha | Adrenergic receptor alpha-2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | adrenergic Alpha2B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50379.83 |
Organism: | NEONATAL RAT |
Description: | adrenergic Alpha2B ADRA2B NEONATAL RAT::P19328 |
Residue: | 453 |
Sequence: | MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLA
AADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS
RALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILA
SSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVP
TLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAE
EGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWW
RRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYC
NSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
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Component 3 |
Name: | Alpha-2A adrenergic receptor [16-465] |
Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
Type: | G-protein coupled receptor |
Mol. Mass.: | 48961.69 |
Organism: | Rattus norvegicus (rat) |
Description: | P22909[16-465] |
Residue: | 450 |
Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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BDBM50042725 |
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n/a |
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Name | BDBM50042725 |
Synonyms: | CHEMBL340471 | N-[1-(4-Fluoro-benzyl)-piperidin-4-yl]-2,3-dimethoxy-benzamide |
Type | Small organic molecule |
Emp. Form. | C21H25FN2O3 |
Mol. Mass. | 372.4332 |
SMILES | COc1cccc(C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)c1OC |
Structure |
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