| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50033666 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162204 (CHEMBL766547) |
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| Ki | 8.7±n/a nM |
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| Citation |  Erion, MD; Niwas, S; Rose, JD; Ananthan, S; Allen, M; Secrist, JA; Babu, YS; Bugg, CE; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group. J Med Chem36:3771-83 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50033666 |
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| n/a |
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| Name | BDBM50033666 |
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| Synonyms: | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl trihydrogen diphosphate(ACVDP) | Acyclovir Diphosphate | CHEMBL7193 | {[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethoxy]-hydroxy-diphosphate |
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| Type | Small organic molecule |
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| Emp. Form. | C8H13N5O9P2 |
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| Mol. Mass. | 385.1644 |
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| SMILES | Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1 |
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| Structure | 
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