Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50042828 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_144597 |
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IC50 | 0.800000±n/a nM |
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Citation | MacPherson, LJ; Bayburt, EK; Capparelli, MP; Bohacek, RS; Clarke, FH; Ghai, RD; Sakane, Y; Berry, CJ; Peppard, JV; Trapani, AJ Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem36:3821-8 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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BDBM50042828 |
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n/a |
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Name | BDBM50042828 |
Synonyms: | 4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyrrolidine-2-carboxylic acid | CHEMBL124536 |
Type | Small organic molecule |
Emp. Form. | C16H26N2O5S |
Mol. Mass. | 358.453 |
SMILES | O[C@@H]1C[C@H](N(C1)C(=O)C1CCCCCCC(CS)C(=O)N1)C(O)=O |
Structure |
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