| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50043326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63515 (CHEMBL677265) |
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| IC50 | 0.093000±n/a nM |
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| Citation |  Kikuchi, T; Kubo, K; Ohtaki, T; Suzuki, N; Asami, T; Shimamoto, N; Wakimasu, M; Fujino, M Endothelin-1 analogues substituted at both position 18 and 19: highly potent endothelin antagonists with no selectivity for either receptor subtype ETA or ETB. J Med Chem36:4087-93 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_BOVIN | Endothelin receptor ET-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49389.50 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_63513 |
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| Residue: | 441 |
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| Sequence: | MQPLPSLCGRALVALILACGVAGIQAEEREFPPAGATQPLPGTGEMMETPTETSWPGRSN
ASDPRSSATPQIPRGGRMAGIPPRTPPPCDGPIEIKETFKYINTVVSCLVFVLGIIGNST
LLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAKDWPFGVEMCKLVPFIQ
KASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFD
IITSDHIGNKLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITALFYTLMTCEML
RKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQHDPRRCEFL
SFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCL
KFKANDHGYDNFRSSNKYSSS
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| BDBM50043326 |
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| n/a |
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| Name | BDBM50043326 |
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| Synonyms: | CHEMBL438733 | c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-Lys-Gln-c(Cys-Val-Tyr-Phe-Cys)-His-Leu-Asp-Ile-Ile-Trp |
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| Type | Small organic molecule |
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| Emp. Form. | C109H159N25O32S5 |
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| Mol. Mass. | 2491.902 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]2CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
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| Structure | 
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