| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug transporter MdfA |
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| Ligand | BDBM50046509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68323 (CHEMBL680694) |
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| IC50 | 300±n/a nM |
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| Citation |  Nelson, ML; Park, BH; Andrews, JS; Georgian, VA; Thomas, RC; Levy, SB Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines. J Med Chem36:370-7 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug transporter MdfA |
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| Name: | Multidrug transporter MdfA |
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| Synonyms: | Chloramphenicol resistance pump cmr | MDFA_ECOLI | Multidrug translocase mdfA | cmlA | cmr | mdfA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44327.48 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_68323 |
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| Residue: | 410 |
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| Sequence: | MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTA
YLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLC
FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAAL
AAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIA
QSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLL
VAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLI
FTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG
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| BDBM50046509 |
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| n/a |
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| Name | BDBM50046509 |
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| Synonyms: | 4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-(3-methyl-butylsulfanylmethyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide | CHEMBL333888 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34N2O8S |
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| Mol. Mass. | 546.632 |
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| SMILES | CC(C)CCSC[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(=O)C(C(N)=O)C(=O)[C@@]3(O)C(=O)C2C(=O)c2c(O)cccc12 |
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| Structure | 
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