Reaction Details |
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Target | Multidrug transporter MdfA |
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Ligand | BDBM50046510 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_68323 (CHEMBL680694) |
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IC50 | 400±n/a nM |
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Citation | Nelson, ML; Park, BH; Andrews, JS; Georgian, VA; Thomas, RC; Levy, SB Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines. J Med Chem36:370-7 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Multidrug transporter MdfA |
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Name: | Multidrug transporter MdfA |
Synonyms: | Chloramphenicol resistance pump cmr | MDFA_ECOLI | Multidrug translocase mdfA | cmlA | cmr | mdfA |
Type: | PROTEIN |
Mol. Mass.: | 44327.48 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_68323 |
Residue: | 410 |
Sequence: | MQNKLASGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTA
YLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLC
FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWIHVLPWEGMFVLFAAL
AAISFFGLQRAMPETATRIGEKLSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIA
QSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSLIIMGGWPIMIGLL
VAAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTVSAAMGMLQMLI
FTVGIEISKHAWLNGGNGLFNLFNLVNGILWLSLMVIFLKDKQMGNSHEG
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BDBM50046510 |
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n/a |
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Name | BDBM50046510 |
Synonyms: | 4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-isobutylsulfanylmethyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide | CHEMBL122262 |
Type | Small organic molecule |
Emp. Form. | C26H32N2O8S |
Mol. Mass. | 532.606 |
SMILES | CC(C)CSC[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(=O)C(C(N)=O)C(=O)[C@@]3(O)C(=O)C2C(=O)c2c(O)cccc12 |
Structure |
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