Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50047721 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_226569 (CHEMBL848647) |
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Ki | 4.3±n/a nM |
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Citation | He, XS; Bowen, WD; Lee, KS; Williams, W; Weinberger, DR; de Costa, BR Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites. J Med Chem36:566-71 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50047721 |
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n/a |
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Name | BDBM50047721 |
Synonyms: | CHEMBL151136 | [2-(3-Bromo-phenyl)-ethyl]-methyl-(2-pyrrolidin-1-yl-ethyl)-amine |
Type | Small organic molecule |
Emp. Form. | C15H23BrN2 |
Mol. Mass. | 311.261 |
SMILES | CN(CCN1CCCC1)CCc1cccc(Br)c1 |
Structure |
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