| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50022243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153329 (CHEMBL760481) |
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| Ki | 800±n/a nM |
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| Citation |  Chern, JW; Lee, HY; Chen, CS; Shewach, DS; Daddona, PE; Townsend, LB Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. J Med Chem36:1024-31 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50022243 |
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| n/a |
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| Name | BDBM50022243 |
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| Synonyms: | 2,8-Diamino-1,9-dihydro-purin-6-one | 8-AMINOGUANINE | CHEMBL8040 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H6N6O |
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| Mol. Mass. | 166.1407 |
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| SMILES | Nc1nc2nc(N)[nH]c(=O)c2[nH]1 |
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| Structure | 
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