| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Ligand | BDBM50008950 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_4174 (CHEMBL875417) |
|---|
| IC50 | 2500±n/a nM |
|---|
| Citation |  Mullican, MD; Wilson, MW; Connor, DT; Kostlan, CR; Schrier, DJ; Dyer, RD Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents. J Med Chem36:1090-9 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 78082.31 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1432947 |
|---|
| Residue: | 673 |
|---|
| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
|
|
|
|---|
| BDBM50008950 |
|---|
| n/a |
|---|
| Name | BDBM50008950 |
|---|
| Synonyms: | 3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one | 3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one(KME-4) | 3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-dihydro-furan-2-one | CHEMBL8562 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H26O3 |
|---|
| Mol. Mass. | 302.4079 |
|---|
| SMILES | CC(C)(C)c1cc(\C=C2/CCOC2=O)cc(c1O)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
