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TargetPolyunsaturated fatty acid 5-lipoxygenase
LigandBDBM50046908
Substrate/Competitorn/a
Meas. Tech.ChEMBL_4176 (CHEMBL619242)
IC50 4500±n/a nM
Citation Mullican, MDWilson, MWConnor, DTKostlan, CRSchrier, DJDyer, RD Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents. J Med Chem36:1090-9 (1993) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Polyunsaturated fatty acid 5-lipoxygenase
Name:Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT
Type:PROTEIN
Mol. Mass.:78082.31
Organism:Rattus norvegicus
Description:ChEMBL_1432947
Residue:673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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  Blast E-value cutoff:
BDBM50046908
n/a
NameBDBM50046908
Synonyms:5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one | CHEMBL12234
TypeSmall organic molecule
Emp. Form.C16H23N3O2
Mol. Mass.289.3727
SMILESCC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1n[nH]c(=O)[nH]1
Structure
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