| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50028122 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54591 (CHEMBL667314) |
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| Ki | 560±n/a nM |
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| Citation |  Kotake, Y; Iijima, A; Yoshimatsu, K; Tamai, N; Ozawa, Y; Koyanagi, N; Kitoh, K; Nomura, H Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids. J Med Chem37:1616-24 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50028122 |
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| n/a |
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| Name | BDBM50028122 |
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| Synonyms: | 2-Amino-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one | 2-Amino-4a,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one | 2-Amino-7H-pyrrolo[2,3-d]pyrimidin-4-ol |
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| Type | Small organic molecule |
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| Emp. Form. | C6H6N4O |
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| Mol. Mass. | 150.138 |
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| SMILES | Nc1nc2[nH]ccc2c(=O)[nH]1 |
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| Structure | 
|
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