| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Substance-P receptor |
|---|
| Ligand | BDBM50030177 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_205786 (CHEMBL812414) |
|---|
| IC50 | 5.4±n/a nM |
|---|
| Citation |  Hagiwara, D; Miyake, H; Igari, N; Karino, M; Maeda, Y; Fujii, T; Matsuo, M Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds. J Med Chem37:2090-9 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Substance-P receptor |
|---|
| Name: | Substance-P receptor |
|---|
| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 46261.42 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
|---|
| Residue: | 407 |
|---|
| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
|
|
|
|---|
| BDBM50030177 |
|---|
| n/a |
|---|
| Name | BDBM50030177 |
|---|
| Synonyms: | (R)-4-Hydroxy-1-(1-methyl-1H-indole-3-carbonyl)-pyrrolidine-2-carboxylic acid [(R)-2-(4-amino-phenyl)-1-(benzyl-methyl-carbamoyl)-ethyl]-amide; hydrochloride | CHEMBL554413 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H35N5O4 |
|---|
| Mol. Mass. | 553.6514 |
|---|
| SMILES | CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
