Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50030210 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205786 (CHEMBL812414) |
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IC50 | 3.5±n/a nM |
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Citation | Hagiwara, D; Miyake, H; Igari, N; Karino, M; Maeda, Y; Fujii, T; Matsuo, M Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds. J Med Chem37:2090-9 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 46261.42 |
Organism: | GUINEA PIG |
Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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BDBM50030210 |
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n/a |
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Name | BDBM50030210 |
Synonyms: | (R)-1-[1-(2-Dimethylamino-ethyl)-1H-indole-3-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylic acid [(R)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethyl]-amide; hydrochloride | CHEMBL539762 |
Type | Small organic molecule |
Emp. Form. | C35H41N5O4 |
Mol. Mass. | 595.7311 |
SMILES | CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc12 |
Structure |
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