Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | ||
| Ligand | BDBM50039285 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_205220 (CHEMBL816494) | ||
| Ki | 820±n/a nM | ||
| Citation |  Frye, SV; Haffner, CD; Maloney, PR; Mook, RA; Dorsey, GF; Hiner, RN; Cribbs, CM; Wheeler, TN; Ray, JA; Andrews, RC 6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase. J Med Chem37:2352-60 (1994) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | |||
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | ||
| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 29472.80 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P18405 | ||
| Residue: | 259 | ||
| Sequence: |
| ||
| BDBM50039285 | |||
| n/a | |||
| Name | BDBM50039285 | ||
| Synonyms: | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid tert-butylamide | 9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid tert-butylamide | CHEMBL76192 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H36N2O2 | ||
| Mol. Mass. | 372.5441 | ||
| SMILES | CC(C)(C)NC(=O)[C@H]1CCC2C3CN=C4CC(=O)CC[C@]4(C)C3CC[C@]12C |t:13| | ||
| Structure | 
| ||