| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50039277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205220 (CHEMBL816494) |
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| Ki | 1.1±n/a nM |
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| Citation |  Frye, SV; Haffner, CD; Maloney, PR; Mook, RA; Dorsey, GF; Hiner, RN; Cribbs, CM; Wheeler, TN; Ray, JA; Andrews, RC 6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase. J Med Chem37:2352-60 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50039277 |
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| n/a |
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| Name | BDBM50039277 |
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| Synonyms: | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-1-ylamide | CHEMBL306289 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H44N2O2 |
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| Mol. Mass. | 464.6826 |
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| SMILES | CC1C(=O)CC[C@]2(C)C3CC[C@@]4(C)C(CC[C@@H]4C(=O)NC45CC6CC(CC(C6)C4)C5)C3CN=C12 |t:37,TLB:27:22:29:26.28.25,27:26:29:22.21.23,THB:25:24:21:26.28.27,25:26:21:24.29.23| |
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| Structure | 
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