Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50039641 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63980 (CHEMBL677606) |
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Ki | 0.06±n/a nM |
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Citation | Subramanyam, C; Bell, MR; Carabateas, P; Court, JJ; Dority, JA; Ferguson, E; Gordon, R; Hlasta, DJ; Kumar, V; Saindane, M 2,6-Disubstituted aryl carboxylic acids, leaving groups"par excellence" for benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem37:2623-6 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50039641 |
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n/a |
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Name | BDBM50039641 |
Synonyms: | 2,6-Dichloro-benzoic acid 4-sec-butyl-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL91944 |
Type | Small organic molecule |
Emp. Form. | C19H17Cl2NO5S |
Mol. Mass. | 442.313 |
SMILES | CCC(C)c1cccc2c1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O |
Structure |
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