| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM50043901 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_45049 (CHEMBL658047) |
|---|
| Ki | 3.6±n/a nM |
|---|
| Citation |  Hunt, CA; Mallorga, PJ; Michelson, SR; Schwam, H; Sondey, JM; Smith, RL; Sugrue, MF; Shepard, KL 3-substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors. J Med Chem37:240-7 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM50043901 |
|---|
| n/a |
|---|
| Name | BDBM50043901 |
|---|
| Synonyms: | CHEMBL309950 | N-[2-(2-Methoxy-ethoxy)-ethyl]-N-(2-methoxy-ethyl)-2-(2,4,4-trioxo-6-sulfamoyl-1,2,3,4-tetrahydro-4lambda*6*-thieno[2,3-b][1,4]thiazin-3-yl)-acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H25N3O9S3 |
|---|
| Mol. Mass. | 499.579 |
|---|
| SMILES | COCCOCCN(CCOC)C(=O)CC1C(=O)Nc2cc(sc2S1(=O)=O)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
