| Reaction Details |
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 | Report a problem with these data |
| Target | Glyceraldehyde-3-phosphate dehydrogenase |
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| Ligand | BDBM50030949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72902 (CHEMBL684096) |
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| IC50 | 1300±n/a nM |
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| Citation |  Verlinde, CL; Callens, M; Van Calenbergh, S; Van Aerschot, A; Herdewijn, P; Hannaert, V; Michels, PA; Opperdoes, FR; Hol, WG Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem37:3605-13 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glyceraldehyde-3-phosphate dehydrogenase |
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| Name: | Glyceraldehyde-3-phosphate dehydrogenase |
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| Synonyms: | G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36060.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1511315 |
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| Residue: | 335 |
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| Sequence: | MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
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| BDBM50030949 |
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| n/a |
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| Name | BDBM50030949 |
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| Synonyms: | (2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | CHEMBL124807 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15N5O4S |
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| Mol. Mass. | 349.365 |
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| SMILES | Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(nc12)-c1cccs1 |
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| Structure | 
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