Ki Summary

Reaction Details

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Target

Glutamate dehydrogenase 1, mitochondrial

Ligand

BDBM50192456

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_71836 (CHEMBL683667)

3400±n/a nM

Citation

Goldstein, BM; Li, H; Jones, JP; Bell, JE; Zeidler, J; Pankiewicz, KW; Watanabe, KA CNAD: a potent and specific inhibitor of alcohol dehydrogenase. J Med Chem37:392-9 (1994) [PubMed]

More Info.:

Get all data from this article, Assay Method

Glutamate dehydrogenase 1, mitochondrial

Name:

Glutamate dehydrogenase 1, mitochondrial

Synonyms:

DHE3_BOVIN | GLUD | GLUD1 | Glutamate dehydrogenase

Type:

PROTEIN

Mol. Mass.:

61518.81

Organism:

Bos taurus

Description:

ChEMBL_71835

Residue:

558

Sequence:

MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLVPPARRHYSEAAADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRSILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGVDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCITVGESDGSIWNPDGIDPKELEDFKLQHGTILG
FPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLNNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFRVYNEAGVTFT

BDBM50192456

n/a

Name

BDBM50192456

Synonyms:

[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(3R,4S)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate

Type

Small organic molecule

Emp. Form.

C21H27N7O14P2

Mol. Mass.

663.4262

SMILES

NC(=O)C1=CN(C=CC1)C1OC(COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O |c:6,t:3|

Structure