| Reaction Details |
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 | Report a problem with these data |
| Target | Kynureninase |
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| Ligand | BDBM50040567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_91724 (CHEMBL702022) |
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| IC50 | 100000±n/a nM |
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| Citation |  Pellicciari, R; Natalini, B; Costantino, G; Mahmoud, MR; Mattoli, L; Sadeghpour, BM; Moroni, F; Chiarugi, A; Carpenedo, R Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J Med Chem37:647-55 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynureninase |
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| Name: | Kynureninase |
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| Synonyms: | KYNU_RAT | Kynu |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52470.50 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_91725 |
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| Residue: | 464 |
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| Sequence: | MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLS
LVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLM
KDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHG
LDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAG
HAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKP
ALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRK
SILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEK
RGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN
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| BDBM50040567 |
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| n/a |
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| Name | BDBM50040567 |
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| Synonyms: | CHEMBL158499 | ortho-nitrobenzoyl)alanine |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2O5 |
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| Mol. Mass. | 238.1968 |
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| SMILES | [NH3+]C(CC(=O)c1ccccc1[N+]([O-])=O)C([O-])=O |
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| Structure | 
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